Season Twelve is the twelfth season of Squidbillies and contains over nine episodes.
- "Forever Autumn"
- "Muscadine Wine"
- "The Reenactment of the Repulsion of the Siege of Cuyler Mountain"
- "Rich Dan, Poor Dan"
- "Cooler-Heads Prevail"
- "Blue Lives Battered"
- "There's Sucker Porn Every Minute"
- "Events by Russell"
- Squidbillies is the first ever Adult Swim show to earn a official twelve season.
- The twenty-two minute-special "Muscadine Wine", is the only episode of the season to not air alongside a different episode on the same night. Due to this episode being over twenty-two minutes long.
- This is the first season of the show where two different episodes air on Sunday nights, The second being Season 13.
- This is the first season to not feature Boyd because his voice actor Pete Smith retired, while Boyd was then killed off in "Dove In An Iron Cage."
- Krystal is seen in a bikini in most of her appearances in this season. The only episode that she is in normal clothes is the episode "There's Sucker Porn Every Minute."
- This is the final season where Unknown Hinson voices Early Cuyler.
- This was the third season to contain over nine episodes, with the other seasons being Season 8 and Season 10.